Light Sensitivity Within Areas of Geographic Atrophy Secondary to Age-Related Macular Degeneration


To investigate residual sensitivity within geographic atrophy (GA) secondary to age-related macular degeneration. to the atrophy boundary. The false-positive response rate was determined with suprathreshold stimuli to the optic disc (Heijl-Krakau method) and used to compute the expected sensitivity measurements for the assumption of absolute scotomata. The outermost visible retinal layer on spectral-domain optical coherence tomography at the location of each test point was determined. 0.001). There was no effect of fixation stability or any other reliability index on this discrepancy. Measured sensitivities within the inner junctional zone of GA may not be purely explained by patient-specific false-positive response rates or other reliability indices. The marked influence of the outer retinal configuration on measured sensitivity may be indicative of residual cone function within GA at the inner junctional zone.

Invest Ophthalmol Vis Sci