Modeling of atrophy size trajectories: variable transformation, prediction and age-of-onset estimation


To model the progression of geographic atrophy (GA) in patients with age-related macular degeneration (AMD) by building a suitable statistical regression model for GA size measurements obtained from fundus autofluorescence imaging. . Model evaluation is performed on data collected for two longitudinal, prospective multi-center cohort studies on GA size progression. 6.49 years. We provide a comprehensive framework for modeling the course of uni- or bilateral GA size progression in longitudinal observational studies. Specifically, the model allows for age-of-onset estimation, identification of risk factors and prediction of future GA size. A square-root transformation of atrophy size is recommended before model fitting.

BMC Med Res Methodol